Dihydroergotamine Mesylate - Dihydroergotamine - Injectable Brand Drug

General Information

• Below is miscellaneous information regarding Dihydroergotamine Mesylate.
• D.H.E.45
• dye-HI-dro-er-GOT-uh-meen

Warning

• Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (for example, potent CYP 3A4 enzyme inhibitors).
• Do not take this medication with macrolide antibiotics (for example, erythromycin, clarithromycin, troleandomycin), protease inhibitors (for example, ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (for example, ketoconazole, itraconazole).

Dihydroergotamine Mesylate Miscellaneous Notes

• Do not share this medication with others.
• Laboratory and/or medical tests may be performed to monitor your progress.

Medicinal Applications

• Dihydroergotamine is used to treat migraine headaches and cluster headaches.
• It is not recommended for migraines affecting only one side of the brain (hemiplegic migraine), the base of the brain/neck area (basilar migraine), or to prevent migraines from occurring.

Drug Compatibility Recommendations

• This drug is not recommended for use with.

What To Do In Case Of Missed Dose

• Not applicable.

Read Before Using Dihydroergotamine Mesylate (precautions)

• This medication is not recommended for use if you have the following medical conditions.

Overdose

• If overdose is suspected, contact your local poison control center or emergency room immediately.
• Symptoms of overdose may include.

Other Medicinal Applications

• This drug may also be used to prevent blood clots (for example, thromboembolism, pulmonary embolism) or to treat low blood pressure (postural hypotension).

Dihydroergotamine Mesylate Storage Instructions

• Store at room temperature between 59 and 77 degrees F (15 and 25 degrees C) away from light and moisture.
• Do not refrigerate or freeze this product.

Possible Side Effects

• Dizziness, drowsiness, headache, nausea, vomiting, diarrhea, flushing, or increased sweating may occur.
• If any of these effects persist or worsen, notify your doctor.
• Tell your doctor immediately if any of these unlikely but serious side effects occur.

Usage Instructions

• Learn how to prepare and inject this drug and review the dihydroergotamine Patient Information Sheet with your doctor or pharmacist.
• Inject this medication into a vein (IV), into a muscle (IM), or under the skin (SC), as directed by your doctor.
• The dosage is based on your medical condition and response to therapy.
• If your headache returns or you have no relief from the first dose, the dose may be repeated 1 hour after the first dose; but only if instructed to do so by your doctor.
• If giving this medication by the IM or SC route, a third dose may be given, if needed, 1 hour after the second dose.
• If any of the dosing information is unclear, consult your doctor or pharmacist.
• If given IM or SC, do not exceed 3 ml of this medication in a 24-hour time period.
• If given IV, do not exceed 2 ml of this medication in a 24-hour time period.
• Do not use daily on a regular basis.
• Do not exceed giving 6 ml of this medication in a one-week time period.
• Before using, check this product visually for particles or discoloration.
• If either is present, do not use the liquid.
• Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise.
• Learn how to store and discard needles and medical supplies safely.
• Consult your pharmacist.