Rapamune - Sirolimus - Oral Brand Drug

General Information

• Below is miscellaneous information regarding Rapamune.
• Rapamune
• sir-oh-LEE-muss

Medicinal Applications

• This medication is used to prevent the rejection of transplanted organs (for example, kidney).

What To Do In Case Of Missed Dose

• If you miss a dose, use it as soon as you remember.
• If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
• Do not double the dose to catch up.

Possible Side Effects

• Nausea, diarrhea, or trouble sleeping may occur.
• If any of these effects persist or worsen, notify your doctor promptly.
• Tell your doctor immediately if you have any of these serious side effects.

Usage Instructions

• Take this medication by mouth once daily, exactly as prescribed by your doctor.
• The dosage depends on your condition and response to therapy.
• Learn all preparation and usage instructions in the product package.
• Ask your doctor or pharmacist if you have questions about any of the information.
• Mix the prescribed dose of this medication with at least two ounces (1/4 cup, 60 ml) of water or orange juice in a plastic or glass container.
• Stir vigorously and drink immediately.
• Refill the container with at least four more ounces (1/2 cup, 120 ml) of water or orange juice, stir vigorously and drink immediately.
• Do not use grapefruit juice to dilute this medication.
• Avoid grapefruit juice while using this medication unless your doctor specifically instructs you otherwise.
• This medication works best when the amount of medicine in your body is kept at a constant level.
• Therefore, take this drug at evenly spaced intervals (for example, every 24 hours) and take this drug consistently with or without food.
• Other medications (for example, antibiotics, other immunosuppressants such as cyclosporine) may be prescribed to prevent infections, and prevent rejection of the transplanted organ.
• Take these medications exactly as prescribed by your doctor.
• If you use certain brands/types of cyclosporine (for example, Neoral, SangCya), take sirolimus four hours after your dose of cyclosporine.
• Consult your pharmacist for more information.
• If a syringe is used to measure the prescribed dose, use a new syringe for each dose.
• Discard used syringes safely and properly.

Rapamune Storage Instructions

• Store at refrigerator temperature between 36 and 46 degrees F (2 to 8 degrees C) away from light and moisture.
• Once opened, bottles containing this drug should be used within 30 days.
• When refrigerated, this product may develop a slight haze.
• If this haze occurs, allow the drug to stand at room temperature and shake gently until the haze disappears.
• The haze does not affect the quality of the drug.

Warning

• This medication may make you more likely to develop an infection or certain types of cancer (for example, lymphoma, skin cancer).
• Notify your doctor immediately if you develop any signs of infection such as fever, chills, sore throat, white patches in your mouth or a change in vaginal discharge.
• Also notify your doctor immediately if you have unusual lumps, swollen glands, unusual sweating or unexplained weight loss.
• When sirolimus has been used in liver transplants, an infrequent but potentially fatal liver problem has occurred (hepatic artery thrombosis).
• Use of this medication to prevent rejection of liver transplants is not recommended.
• Notify your doctor immediately if you develop.

Read Before Using Rapamune (precautions)

• Tell your doctor your medical history, including.

Drug Compatibility Recommendations

• Tell your doctor of all prescription and nonprescription medication you may use, especially of.

What To Do In Case Of Medical Emergency

• Your condition can cause complications in a medical emergency.
• For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

Rapamune Miscellaneous Notes

• Do not share this medication with others.
• Keep all scheduled medical appointments.
• Laboratory and medical tests will be performed to monitor your progress.

Overdose

• If overdose is suspected, contact your local poison control center or emergency room immediately.
• Symptoms of overdose may include irregular heartbeat.